This week's Statistics Seminar Speaker will be Yuval Nov from the University of Haifa.
Modeling and Optimization of Genetic Screens via RNA interference and FACS
We study mathematically a method for discovering which (supposedly single) gene is related to a cell characteristic ("phenotype") of interest. The method is based on RNA interference -- a molecular process for gene deactivation -- and on coupling the phenotype with fluorescence in a FACS machine. A small number of candidate genes are thus isolated, and then tested individually. We model probabilistically this process, prove a limit theorem for its outcome, and derive operational guidelines for maximizing the probability of successful gene detection.
Joint work with Yair Goldberg.
Refreshments will be served after the seminar in 1181 Comstock Hall.